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Welcome to the April 2020 edition of the IVVN Newsletter!

Fourth round of pump-priming grants awarded


This week, we announced the three projects funded in the fourth round of our pump-priming grants. These grants, worth up to £100,000, are awarded to members for projects that aim to address a key bottleneck preventing the development of a vaccine.

The three successful projects will see 12 researchers working across five countries to develop vaccines against contagious bovine pleuropneumonia, bovine babesiosis and avian influenza. Find out more about each of the projects here.

COVID-19 updates


Over the coming weeks and months, we want to highlight our members' coronavirus research, as well as relevant COVID-19 publications and resources.

Interview with Bent Frandsen, CEO of ExpreS²ion Biotechnologies

We spoke with IVVN member Bent Frandsen, CEO of ExpreS²ion Biotechnologies, about his organisation’s involvement in an EU consortium to rapidly develop a COVID-19 vaccine.

Oxford scientists to begin COVID-19 vaccine clinical testing

A team of scientists from the Jenner Institute and Oxford Vaccine Group are to begin clinical testing of a COVID-19 vaccine candidate.

Webinar on COVID-19 in Nigeria

The Usher Institute's sixth COVID-19 webinar will take place on Thursday 30 April 2020 at 13.00 UK time. This week's webinar is titled COVID-19 in Nigeria: What is the way forward? and will be given by Dr Ayoade Olatunbosun-Alakija, Former Chief Humanitarian Coordinator, Nigeria. Register here to join live on Zoom Webinar, where you can also ask questions, or you can watch live or later on YouTube.

Coronavirus: exit strategies

Science Museum Group, 20 April 2020
Roger Highfield, Science Director of the Science Museum Group, outlines the science of lockdowns and how to end the pandemic.

For more articles, publications and resources relating to SARS-CoV2 and the COVID-19 pandemic, visit our dedicated page on the IVVN website.

And if you have a project related to COVID-19 that you would like to share with IVVN members, or if you see an interesting article you would like to share, please let us know.

Searching the members' directory


You can now search the members' database by career stage, scientific discipline, host species, pathogen and the stage of vaccine development members are involved in. This article on our website will tell you everything you need to know about the new search terms.

Add in your details now: Those of you who haven't added your details can do so by logging in to the website, clicking the 'Edit' button on your profile and selecting the options that are relevant to your research or area of work.

Missing pathogen? If you can't see what you're working on listed as an option, please let us know, and we'll add it in.

Members' survey


Thank you to everyone who responded to our members' survey. Every response will be important in shaping the future of the network. We will go through each of the responses over the next few weeks and report the survey's findings in a future newsletter and on our website. In the meantime, if you have any additional feedback about the Network, we will be happy to hear from you.

Call for blogs


We are currently looking for research institutes and projects, especially in low- and middle-income countries, to feature on our blog. This is a great opportunity to let more people know about the research that goes on at your institute and find potential new collaborators. If you would like to hear more about what we're looking for, get in touch.

Articles


African swine fever outbreak reported in western Poland

Wojciech Kość and Michael Standaert
The Guardian, 8 April 2020

Funding


BactiVac Network: pump-priming funding for projects on vaccines against bacterial diseases (apply by 17 May)
Future Leaders – African Independent Research (FLAIR) Fellowships 2021 (apply by 27 May)
BBSRC Discovery Fellowships (UK) (deadline extended: apply by 11 June)
VALIDATE Network: training grants (apply by 17 June)
Click here to view all funding opportunities

Publications


Nayak SK (2020) Current prospects and challenges in fish vaccine development in India with special reference to Aeromonas hydrophila vaccine. Fish & Shellfish Immunology 100:283-299. doi:10.1016/j.fsi.2020.01.064.

Reverter M, Sarter S, Caruso D, Avarre J-C, Combe M, Pepey E, Pouyaud L, Vega-Heredía S, de Verdal H and Gozlan RE (2020) Aquaculture at the crossroads of global warming and antimicrobial resistance. Nature Communications 11:1870. doi:10.1038/s41467-020-15735-6.

Lazarus DD, Peta F, Blight D, Van Heerden J, Mutowembwa PB, Heath L, Blignaut B, Opperman PA and Fosgate GT (2020) Efficacy of a foot-and-mouth disease vaccine against a heterologous SAT1 virus challenge in goats. Vaccine. doi:10.1016/j.vaccine.2020.04.014.

Amanat F and Krammer F (2020) SARS-CoV-2 vaccines: status report. Immunity 52:583-589. doi:10.1016/j.immuni.2020.03.007.

Thanh Le T, Andreadakis Z, Kumar A, Gómez Román R, Tollefsen S, Saville M and Mayhew S (2020) The COVID-19 vaccine development landscape. Nature Reviews Drug Discovery. doi:10.1038/d41573-020-00073-5.

Dinga JN, Perimbie SN, Gamua SD, Chuma FNG, Njimoh DL, Djikeng A, Pelle R and Titanji VPK (2020) Analysis of the role of TpUB05 antigen from Theileria parva in immune responses to malaria in humans compared to its homologue in Plasmodium falciparum the UB05 antigen. Pathogens 9. doi:10.3390/pathogens9040271.

Decaro N, Martella V, Saif LJ and Buonavoglia C (2020) COVID-19 from veterinary medicine and one health perspectives: what animal coronaviruses have taught us . Research in Veterinary Science 131:21-23. doi:10.1016/j.rvsc.2020.04.009.

Thwaite R, Berbel C, Aparicio M, Torrealba D, Pesarrodona M, Villaverde A, Borrego JJ, Manchado M and Roher N (2020) Nanostructured recombinant protein particles raise specific antibodies against the nodavirus NNV coat protein in sole. Fish & Shellfish Immunology 99:578-586. doi:10.1016/j.fsi.2020.02.029.

Asfor A, Howe N, Grazioli S, Berryman S, Parekh K, Wilsden G, Ludi A, King DP, Parida S, Brocchi E and Tuthill TJ (2020) Detection of bovine antibodies against a conserved capsid epitope as the basis of a novel universal serological test for foot-and-mouth disease. Journal of Clinical Microbiology. doi:10.1128/JCM.01527-19.

Mumin FI, Emikpe BO and Odeniyi D (2020) Evaluation of mucoadhesive property and the effect of Boswellia carteri gum on intranasal vaccination against small ruminant morbillivirus infection (PPR). Journal of Immunoassay and Immunochemistry. doi:10.1080/15321819.2020.1734935.

Bishop RP, Odongo D, Ahmed J, Mwamuye M, Fry LM, Knowles DP, Nanteza A, Lubega G, Gwakisa P, Clausen PH and Obara I (2020) A review of recent research on Theileria parva: implications for the infection and treatment vaccination method for control of East Coast fever. Transboundary and Emerging Diseases 67(1):56-67. doi:10.1111/tbed.13325.

Yoo D, Kim H, Lee JY and Yoo HS (2020) African swine fever: etiology, epidemiological status in Korea, and perspective on control. Journal of Veterinary Science 21:e38. doi:10.4142/jvs.2020.21.e38.

de la Fuente J, Estrada-Peña A and Contreras M (2020) Modeling tick vaccines: a key tool to improve protection efficacy. Expert Review of Vaccines 19:217-225. doi:10.1080/14760584.2020.1745635.

Biswal JK, Subramaniam S, Ranjan R, VanderWaal K, Sanyal A, Pattnaik B and Singh RK (2020) Differential antibody responses to the major antigenic sites of FMD virus serotype O after primo-vaccination, multiply-vaccination and after natural exposure. Infection, Genetics and Evolution 78:104105. doi:10.1016/j.meegid.2019.104105.

Soutter F, Werling D, Tomley FM and Blake DP (2020) Poultry coccidiosis: design and interpretation of vaccine studies. Frontiers in Veterinary Science 7:101. doi:10.3389/fvets.2020.00101.

Jégouzo SAF, Nelson C, Hardwick T, Wong STA, Lau NKK, Neoh GKE, Castellanos-Rueda R, Huang Z, Mignot B, Hirdaramani A, Howitt A, Frewin K, Shen Z, Fox RJ, Wong R, Ando M, Emony L, Zhu H, Holder A, Werling D, Krishnan N, Robertson BD, Clements A, Taylor ME and Drickamer K (2020) Mammalian lectin arrays for screening host-microbe interactions. Journal of Biological Chemistry. doi:10.1074/jbc.RA120.012783.

Sang H, Miller G, Lokhandwala S, Sangewar N, Waghela SD, Bishop RP and Mwangi W (2020) Progress toward development of effective and safe African swine fever virus vaccines. Frontiers in Veterinary Science 7:84. doi:10.3389/fvets.2020.00084.

Gorain C, Singh A, Bhattacharyya S, Kundu A, Lahiri A, Gupta S and Mallick AI (2020) Mucosal delivery of live Lactococcus lactis expressing functionally active JlpA antigen induces potent local immune response and prevent enteric colonization of Campylobacter jejuni in chickens. Vaccine 38:1630-1642. doi:10.1016/j.vaccine.2019.12.064.

Herzog CM, de Glanville WA, Willett BJ, Cattadori IM, Kapur V, Hudson PJ, Buza J, Swai ES, Cleaveland S and Bjørnstad ON (2020) Identifying age cohorts responsible for peste des petits ruminants virus transmission among sheep, goats, and cattle in northern Tanzania. Journal 12(2):186. doi:10.3390/v12020186.

Lahiri A, Sharif S and Mallick AI (2020) Intragastric delivery of recombinant Lactococcus lactis displaying ectodomain of influenza matrix protein 2 (M2e) and neuraminidase (NA) induced focused mucosal and systemic immune responses in chickens. Molecular Immunology 114:497-512. doi:10.1016/j.molimm.2019.08.015.

Singh A, Nisaa K, Bhattacharyya S and Mallick AI (2020) Immunogenicity and protective efficacy of mucosal delivery of recombinant hcp of Campylobacter jejuni Type VI secretion system (T6SS) in chickens. Molecular Immunology 111:182-197. doi:10.1016/j.molimm.2019.04.016.

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