Welcome to the August 2020 edition of the IVVN Newsletter!

Our 2020 Annual Report is out now. This is our third Annual Report since the Network launched in August 2017. It contains news about all our activities over the past 12 months, including workshops, two rounds of pump-priming and laboratory exchange funding, the latest from the IVVN African Schools Outreach Programme and news from our community. The report is available here.

Highlights from the report

Results of the 2020 members' survey

Earlier this year, we sent all members a link to a questionnaire about the Network. We asked respondents about the challenges and barriers facing their research and careers, their experiences with IVVN funding applications, what they thought of our activities, and what additional opportunities we should offer in the future. You will find the results in full starting on page 7 of the report.

Updates on the Network's membership

Since launching three years ago, our membership has grown considerably, and we now have more than 1,250 members in 83 countries around the world. This year, we also launched new search terms to make it easier to find members that work on particular pathogens, host species, and scientific areas.

IVVN-funded research: newly funded and completed projects

One of the IVVN features most valued by members is our catalyst funding work. Our pump-priming, laboratory exchange and newly launched fellowship schemes allow members around the world to collaborate on exciting science to address research gaps and vaccine development bottlenecks. This year's Annual Report summarises the six pump-priming and eight laboratory exchange grants we have awarded over the past 12 months. You can also read about the outcomes of completed projects funded in the first and second round of awards.

Latest from our outreach pogramme in Africa

The past year has also seen the expansion of the IVVN African Schools Outreach Programme. In October 2019, the IVVN and Easter Bush Science Outreach Centre teams travelled to the University of Pretoria in South Africa to train seven scientists from South Africa, Ethiopia and Uganda. These seven scientists will now be visiting schools in their home countries to deliver the Rabies Lab interactive workshop. And this year, the workshop was delivered in Zambia for the first time, with six scientists from the University of Zambia and the Central Veterinary Research Institute taking their mobile laboratory to Lusaka Girls Secondary School. You will find a timeline of the programme's activities on page 20 of the report.

Download the report here

Webinar: One Health, COVID-19 and veterinary vaccination

We are pleased to announce that Dr Michael Francis, BioVacc Consulting Ltd, UK, will give a live webinar for IVVN members on Wednesday 30 September at 1pm BST. The 30 minute talk will be titled 'One health, COVID-19 and lessons from veterinary vaccination' and will be followed by the opportunity to ask questions. The webinar will be free to attend, but you must register to receive your joining link and instructions. More details and registration here.

Abstract

This webinar will explore the link between the ‘One Health’ agenda, veterinary vaccination and COVID-19 control. It will review the relevant observations from five existing animal health coronavirus vaccines and discuss how these may provide useful data for the development of a vaccine against SARS-CoV-2 infection. The use of novel vaccine ‘platform’ technologies within veterinary medicine will be reviewed and examples of how a One Health approach can be applied to vaccination will be presented. Finally, a brief update will be provided on the current status of COVID-19 vaccine development and a summary of the lessons to be aware of from the work on existing veterinary coronavirus vaccines will be discussed.

Details

When: Wednesday 30 September, 13.00−13.45 BST
Where: Online
Registration: Free

More information and registration here

Covid-19 updates

As the Covid-19 pandemic continues, we're highlighting relevant publications and resources, including webinars, publications and other resources. You can find them all on our dedicated Covid-19 page:

Podcast: South Africa’s second COVID-19 vaccine trial explained

Pasha | The Conversation, 26 August 2020
Professor Shabir Madhi, University of the Witwatersrand, explains how South Africa's COVID-19 vaccine trials work.

Knowledge transfer for large-scale vaccine manufacturing

Price WN, Rai AK and Minssen T, Science, 21 August 2020
As efforts to develop COVID-19 vaccines and therapeutics progress, attention is turning to how these products can be manufactured at enormous scale.

COVID-19 in India: State and national responses, economics considerations and next steps

Usher Institute, 18 August 2020
In this webinar, Dr Rijo John from the Centre for Public Policy Research, Kerala, India, spoke about India's response to the pandemic.

For more articles, publications and resources relating to SARS-CoV2 and the Covid-19 pandemic, visit our dedicated page on the IVVN website.

And if you have a project related to Covid-19 that you would like to share with nearly 1,250 IVVN members, or if you see an interesting article you would like to share, please let us know.

Articles

Scientists seek test for cattle parasite infection

Roslin Institute, 11 August 2020
IVVN members and other scientists are seeking to develop a test that could help prevent the devastating impact of trypanosomiasis.

Threat is rising of diseases passed from animals, warns Oxford vaccine professor

The Independent, 30 August 2020
Growing population density, increased international travel and deforestation are believed to be driving the spread of zoonotic-based infections.

Events

14th Vaccine Congress – online edition: combatting the threat of Covid-19

27-28 September 2020

Elsevier and the journal Vaccine will be hosting this year's Vaccine Congress as a free online event in September.

6th World One Health Congress – virtual edition

30 October to 3 November 2020

The organisers of the World One Health Congress have decided to move this year's congress to an online event.

Job vacancies closing soon

Antibody Production Specialist,
The Pirbright Institute, UK

Closing date: 10 September 2020
Salary: £27,355 to £29,083

Postdoctoral Researcher – morbilliviruses,
The Pirbright Institute, UK

Closing date: 10 September 2020
Salary: £32,684 up to £35,104

Click here to view all job opportunities

Funding opportunities

African Research Leader scheme 2020

The UK Medical Research Council and the UK Department for International Development announce a further call for proposals for the prestigious African Research Leader awards.
Deadline: 8 September 2020

Publications

Cattle

**An overview of current knowledge on in vitro Babesia cultivation for production of live attenuated vaccines for bovine babesiosis in Mexico**

Alvarez JA, Rojas C and Figueroa JV
Frontiers in Veterinary Science 7:364. doi:10.3389/fvets.2020.00364

Development and challenges in animal tuberculosis vaccination

Balseiro A, Thomas J, Gortázar C and Risalde MA
Pathogens 9. doi:10.3390/pathogens9060472

Identification of conserved peptides containing B-cell epitopes of Babesia bovis AMA-1 and their potential as diagnostics candidates

Barreda D, Hidalgo-Ruiz M, Hernandez-Ortiz R, Ramos JA, Galindo-Velasco E and Mosqueda J
Transboundary and Emerging Diseases 67:60-68. doi:10.1111/tbed.13213

**A transcriptome and proteome of the tick Rhipicephalus microplus shaped by the genetic composition of its hosts and developmental stage**

Garcia GR, Chaves Ribeiro JM, Maruyama SR, Gardinassi LG, Nelson K, Ferreira BR, Andrade TG and Santos IKF
Scientific Reports 10:12857. doi:10.1038/s41598-020-69793-3

Contagious bovine and caprine pleuropneumonia: a research community's recommendations for the development of better vaccines

Jores J, Baldwin C, Blanchard A, Browning GF, Colston A, Gerdts V, Goovaerts D, Heller M, Juleff N, Labroussaa F, Liljander A, Muuka G, Nene V, Nir-Paz R, Sacchini F, Summerfield A, Thiaucourt F, Unger H, Vashee S, Wang X and Salt J
NPJ Vaccines 5:66. doi:10.1038/s41541-020-00214-2

Vaccination with recombinant subolesin antigens provides cross-tick species protection in Bos indicus and crossbred cattle in Uganda

Kasaija PD, Contreras M, Kabi F, Mugerwa S and de la Fuente J
Vaccines 8. doi:10.3390/vaccines8020319

MANα1-2MAN decorated liposomes enhance the immunogenicity induced by a DNA vaccine against BoHV-1

Kornuta CA, Bidart JE, Soria I, Gammella M, Quattrocchi V, Pappalardo JS, Salmaso S, Torchilin VP, Cheuquepán Valenzuela F, Hecker YP, Moore DP, Zamorano PI and Langellotti CA
Transboundary and Emerging Diseases. doi: 10.1111/tbed.13718

**Baseline analysis of Mycoplasma mycoides subsp. mycoides antigens as targets for a DIVA assay for use with a subunit vaccine for contagious bovine pleuropneumonia**

Lutta HO, Odongo D, Mather A, Perez-Casal J, Potter A, Gerdts V, Berberov EM, Prysliak T, Kyallo M, Kipronoh A, Olum M, Pelle R and Naessens J
BMC Veterinary Research 16:236. doi:10.1186/s12917-020-02453-w

The effect of vaccination with live attenuated Neethling lumpy skin disease vaccine on milk production and mortality - an analysis of 77 dairy farms in Israel

Morgenstern M and Klement E
Vaccines 8. doi:10.3390/vaccines8020324

Fish/aquaculture

Cleaner fish in aquaculture: review on diseases and vaccination

Erkinharju T, Dalmo RA, Hansen M and Seternes T
Reviews in Aquaculture. doi:10.1111/raq.12470

Modelling the effect of vaccination on transmission dynamics of nervous necrosis virus in grouper larvae Epinephelus coioides

Lu TH, Chen CY, Yang YF and Liao CM
Journal of Fish Diseases. doi:10.1111/jfd.13225

Application of outer membrane protein-based vaccines against major bacterial fish pathogens in India

Maiti B, Dubey S, Munang'andu HM, Karunasagar I, Karunasagar I and Evensen Ø
Frontiers in Immunology 11:1362. doi:10.3389/fimmu.2020.01362

Haemato-immunological responses and effectiveness of feed-based bivalent vaccine against Streptococcus iniae and Aeromonas hydrophila infections in hybrid red tilapia (Oreochromis mossambicus × O. niloticus)

Monir MS, Yusoff SBM, Zulperi ZBM, Hassim HBA, Mohamad A, Ngoo MSBMH, Ina-Salwany MY
BMC Veterinary Research 16:226. doi:10.1186/s12917-020-02443-y

Poultry

Development of an effective and stable genotype-matched live attenuated Newcastle disease virus vaccine based on a novel naturally recombinant Malaysian isolate using reverse genetics

Bello MB, Mahamud SNA, Yusoff K, Ideris A, Hair-Bejo M, Peeters BPH and Omar AR
Vaccines 8. doi:10.3390/vaccines8020270

Establishing a robust manufacturing platform for recombinant veterinary vaccines: an adenovirus-vector vaccine to control Newcastle disease virus infections of poultry in sub-Saharan Africa

Farnós O, Gelaye E, Trabelsi K, Bernier A, Subramani K, Kallel H, Yami M and Kamen AA
Vaccines 8(2):338. doi:10.3390/vaccines8020338

Newcastle disease virus as a vaccine vector for 20 years: a focus on maternally derived antibody interference

Hu Z, Ni J, Cao Y and Liu X
Vaccines 8. doi:10.3390/vaccines8020222

Limited cross-protection against infectious bronchitis provided by recombinant infectious bronchitis viruses expressing heterologous spike glycoproteins

Keep S, Sives S, Stevenson-Leggett P, Britton P, Vervelde L and Bickerton E
Vaccines 8. doi:10.3390/vaccines8020330

**Pustulan activates chicken bone marrow-derived dendritic cells in vitro and promotes ex vivo CD4⁺ T cell recall response to infectious bronchitis virus**

Larsen FT, Guldbrandtsen B, Christensen D, Pitcovski J, Kjærup RB and Dalgaard TS
Vaccines 8. doi:10.3390/vaccines8020226

Serodynamic analysis of the piglets born from sows vaccinated with modified live vaccine or E2 subunit vaccine for classical swine fever

Li YC, Chiou MT and Lin CN
Pathohens 9. doi:10.3390/pathogens9060427

**Vaccination with transgenic Eimeria tenella expressing Eimeria maxima AMA1 and IMP1 confers partial protection against high-level E. maxima challenge in a broiler model of coccidiosis**

Pastor-Fernández I, Kim S, Marugán-Hernández V, Soutter F, Tomley FM and Blake DP
Parasites & Vectors 13:343. doi:10.1186/s13071-020-04210-2

A nanoparticle-poly(I:C) combination adjuvant enhances the breadth of the immune response to inactivated influenza virus vaccine in pigs

Renu S, Feliciano-Ruiz N, Lu F, Ghimire S, Han Y, Schrock J, Dhakal S, Patil V, Krakowka S, HogenEsch H and Renukaradhya GJ
Vaccines 8. doi:10.3390/vaccines8020229

Evolutionary analysis of infectious bronchitis virus reveals marked genetic diversity and recombination events

Rohaim MA, El Naggar RF, Abdelsabour MA, Mohamed MHA, El-Sabagh IM and Munir M
Genes 11. doi:10.3390/genes11060605

Nitric oxide production and Fc receptor-mediated phagocytosis as functional readouts of macrophage activity upon stimulation with inactivated poultry vaccines in vitro

van den Biggelaar RH, van Eden W, Rutten VPMG and Jansen CA
Vaccines 8(2):332. doi:10.3390/vaccines8020332

Small ruminants

The potential for vaccines against scour worms of small ruminants

Britton C, Emery DL, McNeilly TN, Nisbet AJ and Stear MJ
International Journal for Parasitology 50:533-553. doi:10.1016/j.ijpara.2020.04.003

A protective bivalent vaccine against Rift Valley fever and bluetongue

Calvo-Pinilla E, Marín-López A, Moreno S, Lorenzo G, Utrilla-Trigo S, Jiménez-Cabello L, Benavides J, Nogales A, Blasco R, Brun A and Ortego J
NPJ Vaccines 5:70. doi:10.1038/s41541-020-00218-y

**Update on peste des petits ruminants status in South East Nigeria: serological and farmers' awareness investigation, and potential risk factors**

Chukwudi IC, Ogbu KI, Nwabueze AL, Olaolu OS, Ugochukwu EI and Chah KF
Tropical Animal Health and Production. doi:10.1007/s11250-020-02359-7

Enhanced immune responses with serum proteomic analysis of hu sheep to foot-and-mouth disease vaccine emulsified in a vegetable oil adjuvant

Cui X, Wang Y, Guan R, Lu M, Yuan L, Xu W and Hu S
Vaccines 8. doi:10.3390/vaccines8020180

Immunological responses and potency of the EG95NC^- recombinant sheep vaccine against cystic echinococcosis

Jazouli M, Lightowlers MW, Bamouh Z, Gauci CG, Tadlaoui K, Ennaji MM and Elharrak M
Parasitology International 78: 102149. doi:10.1016/j.parint.2020.102149

**A novel recombinant Newcastle disease virus vectored DIVA vaccine against peste des petits ruminants in goats**

Murr M, Hoffmann B, Grund C, Römer-Oberdörfer A and Mettenleiter TC
Vaccines 8. doi:10.3390/vaccines8020205

Swine

**Development of attenuated live vaccine candidates against swine brucellosis in a non-zoonotic B. suis biovar 2 background**

Aragón-Aranda B, de Miguel MJ, Lázaro-Antón L, Salvador-Bescós M, Zúñiga-Ripa A, Moriyón I, Iriarte M, Muñoz PM and Conde-Álvarez R
Veterinary Research 51:92. doi:10.1186/s13567-020-00815-8

Development of a marker vaccine candidate against classical swine fever based on the live attenuated vaccine C-strain

Han Y, Xie L, Yuan M, Ma Y, Sun H, Sun Y, Li Y and Qiu HJ
Veterinary Microbiology 247:108741. doi:10.1016/j.vetmic.2020.108741

Experimental PCEP-adjuvanted swine influenza H1N1 vaccine induced strong immune responses but did not protect piglets against heterologous H3N2 virus challenge

Magiri RB, Lai KJ, Mutwiri GK and Wilson HL
Vaccines 8. doi:10.3390/vaccines8020235

Classical swine fever virus biology, clinicopathology, diagnosis, vaccines and a meta-analysis of prevalence: a review from the Indian perspective

Malik YS, Bhat S, Kumar ORV, Yadav AK, Sircar S, Ansari MI, Sarma DK, Rajkhowa TK, Ghosh S and Dhama K
Pathogens 9. doi:10.3390/pathogens9060500

Establishment of a pig influenza challenge model for evaluation of monoclonal antibody delivery platforms

McNee A, Smith TRF, Holzer B, Clark B, Bessell E, Guibinga G, Brown H, Schultheis K, Fisher P, Ramos S, Nunez A, Bernard M, Graham S, Martini V, Chrun T, Xiao Y, Kash JC, Taubenberger JK, Elliott S, Patel A, Beverley P, Rijal P, Weiner DB, Townsend A, Broderick KE and Tchilian E
The Journal of Immunology 205: 648-660. doi:10.4049/jimmunol.2000429

Production of recombinant African swine fever viruses: speeding up the process

Rathakrishnan A, Moffat K, Reis AL and Dixon LK
Viruses 12. doi:10.3390/v12060615

Zoonoses

Middle East respiratory syndrome coronavirus (MERS-CoV): state of the science

Mostafa A, Kandeil A, Shehata M, El Shesheny R, Samy AM, Kayali G and Ali MA
Microorganisms 8(7):991. doi:10.3390/microorganisms8070991

Self-disseminating vaccines to suppress zoonoses

Nuismer SL and Bull JJ
Nature Ecology and Evolution 4:1168-1173. doi:10.1038/s41559-020-1254-y

Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection

Sun H, Xiao Y, Liu J, Wang D, Li F, Wang C, Li C, Zhu J, Song J, Sun H, Jiang Z, Liu L, Zhang X, Wei K, Hou D, Pu J, Sun Y, Tong Q, Bi Y, Chang KC, Liu S, Gao GF and Liu J
PNAS 117:17204-17210. doi:10.1073/pnas.1921186117

Other

Livestock and poultry production in Nepal and current status of vaccine development

Poudel U, Dahal U, Upadhyaya N, Chaudhari S and Dhakal S
Vaccines 8. doi:10.3390/vaccines8020322

View all publications listed on the IVVN website

Have we missed anything? If you have a recent publication that we haven't included, send us the details of your paper and we'll include it in the next edition of the newsletter.

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International Veterinary Vaccinology Network · The Roslin Institute · Easter Bush Campus · Edinburgh, Midlothian EH25 9RG · United Kingdom