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Welcome to the May 2020 edition of the IVVN Newsletter!

COVID-19 updates


As the COVID-19 pandemic continues, we're highlighting our members' work on SARS-CoV-2 vaccines, as well as relevant COVID-19 publications and resources. You can find them all on our dedicated COVID-19 page:

COVID-19 vaccination: lessons to be learned from veterinary coronavirus vaccines

Dr Michael James Francis, IVVN board member and Managing Director of BioVacc Consulting Ltd, discusses vaccines against veterinary coronaviruses and how these could relate to the COVID-19 pandemic.

Interview with Dr Volker Gerdts, Director and CEO of VIDO-InterVac

We spoke with Dr Volker Gerdts, Director and CEO of VIDO-InterVac, about his organisation’s work on developing and testing a subunit vaccine against SARS-CoV-2.

COVID-19 vaccine: the eight main technologies being tested

A vaccine is the most effective and safest way of ending the COVID-19 pandemic. But which vaccine types are being tested and how far have the projects progressed?

Vaccine vialsKeenly-watched COVID-19 vaccine 'won't be expensive', developer says

Reuters, 15 May 2020
The Reuters news agency spoke to Jenner Institute director and IVVN board member Professor Adrian Hill about the Oxford SARS-CoV-2 vaccine candidate.

For more articles, publications and resources relating to SARS-CoV2 and the COVID-19 pandemic, visit our dedicated page on the IVVN website.

And if you have a project related to COVID-19 that you would like to share with IVVN members, or if you see an interesting article you would like to share, please let us know.

Blog: National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand


In our latest blog post, IVVN members Dr Peera Jaru-Ampornpan and Dr Vanvimon Saksmerprome introduce the institute where they work – Thailand's National Center for Genetic Engineering and Biotechnology (BIOTEC). Established in 1983, BIOTEC employs more than 400 research scientists and its research covers a wide range of areas from agricultural science to biomedical and environmental research.

Peera and Vanvimon's blog post discusses the institute's work on aquaculture vaccines, an exciting project that uses algal biotechnology to address viral shrimp diseases and an international research consortium aimed at developing a vaccine against porcine circovirus. You can read the piece here.

Microalgae grown on a plate

Want to get involved? We are currently looking for research institutes and projects, especially in low- and middle-income countries, to feature on our blog. This is a great opportunity to let more people know about the research that goes on at your institute and find potential new collaborators. If you would like to hear more about what we're looking for, get in touch.

AgResults FMD Vaccine Challenge Project


Our friends at GALVmed are implementing the new AgResults Foot and Mouth Disease Vaccine Challenge Project. The project, which is run as an eight-year prize competition, is encouraging the development of new high-quality vaccines that will be instrumental in controlling this viral disease. Read all about the project and how it works here.

Articles


Pirbright African swine fever vaccine protects 100% of pigs from developing severe disease

The Pirbright Institute, 21 May 2020

Vaccine vialsNew livestock data portal aims to drive better decisions and investments

University of Edinburgh, 25 May 2020
Livestockdata.org offers data and evidence on livestock health and productivity in low and middle-income countries

BSI launches Protecting The World report

British Society for Immunology, 29 April 2020
New report, part of the Celebrate Vaccines initiative, champions 200 years of UK vaccine research.

Funding


BBSRC Discovery Fellowships (UK) (deadline extended: apply by 11 June)
VALIDATE Network: training grants (apply by 17 June)
Click here to view all funding opportunities

Publications


A Veterinary Vaccine Development Process Map to assist in the development of new vaccines

Francis MJ (2020) Vaccine,
doi:10.1016/j.vaccine.2020.05.007

Al-Rofaai A and Bell-Sakyi L (2020) Tick cell lines in research on tick control. Frontiers in Physiology 11:152. doi:10.3389/fphys.2020.00152.

Avendaño C, Celis-Giraldo C, Ordoñez D, Díaz-Arévalo D, Rodríguez-Habibe I, Oviedo J, Curtidor H, García-Castiblanco S, Martínez-Panqueva F, Camargo-Castañeda A, Reyes C, Bohórquez MD, Vanegas M, Cantor D, Patarroyo ME and Patarroyo MA (2020) Evaluating the immunogenicity of chemically-synthesised peptides derived from foot-and-mouth disease VP1, VP2 and VP3 proteins as vaccine candidates. Vaccine 38:3942-3951. doi:10.1016/j.vaccine.2020.04.006.

Bessell PR, Woolley R, Stevenson S, Al-Riyami L, Opondo P, Lai L and Gammon N (2020) An analysis of the impact of Newcastle disease vaccination and husbandry practice on smallholder chicken productivity in Uganda. Preventive Veterinary Medicine 177:104975. doi:10.1016/j.prevetmed.2020.104975.

Cackett G, Matelska D, Sýkora M, Portugal R, Malecki M, Bähler J, Dixon L and Werner F (2020) The African swine fever virus transcriptome. Journal of Virology 94. doi:10.1128/JVI.00119-20.

Davies PL, Blanchard AM, Staley CE, Bollard NJ, Coffey TJ, Tötemeyer S (2020) Genomic heterogeneity of Dichelobacter nodosus within and between UK sheep flocks and between age groups within a flock. BMC Microbiology 20:107. doi:10.1186/s12866-020-01769-9.

De Groot AS, Moise L, Terry F, Gutierrez AH, Hindocha P, Richard G, Hoft DF, Ross TM, Noe AR, Takahashi Y, Kotraiah V, Silk SE, Nielsen CM, Minassian AM, Ashfield R, Ardito M, Draper SJ and Martin WD (2020) Better epitope discovery, precision immune engineering, and accelerated vaccine design using immunoinformatics tools. Frontiers in Immunology 11:442. doi:10.3389/fimmu.2020.00442.

Dekker A, Sanz-Bernardo B, Singanallur NB, Ludi AB, Horsington J, Eblé PL, King DP and Vosloo W (2020) Cross-protection induced by a A/MAY/97 emergency vaccine against intra-serotype heterologous challenge with a foot-and-mouth disease virus from the A/ASIA/G-VII lineage. Vaccines (Basel) 8. doi:10.3390/vaccines8010024.

Fatoba AJ and Adeleke MA (2020) Transgenic Eimeria parasite: a potential control strategy for chicken coccidiosis. Acta Tropica 205:105417. doi:10.1016/j.actatropica.2020.105417.

Gao X, Zhao D, Zhou P, Zhang L, Li M, Li W, Zhang Y, Wang Y and Liu X (2020) Characterization, pathogenicity and protective efficacy of a cell culture-derived porcine deltacoronavirus. Virus Research 282:197955. doi:10.1016/j.virusres.2020.197955.

Gowthaman V, Kumar S, Koul M, Dave U, Murthy TRGK, Munuswamy P, Tiwari R, Karthik K, Dhama K, Michalak I, Joshi SK (2020) Infectious laryngotracheitis: etiology, epidemiology, pathobiology, and advances in diagnosis and control - a comprehensive review. Veterinary Quarterly 40:140-161. doi:10.1080/01652176.2020.1759845.

Huang J, Pan C, Sun P, Feng E, Wu J, Zhu L and Wang H (2020) Application of an O-linked glycosylation system in Yersinia enterocolitica serotype O:9 to generate a new candidate vaccine against Brucella abortus. Microorganisms 8(3):436. doi:10.3390/microorganisms8030436.

Huang L, Sun Z, Xia D, Wei Y, Sun E, Liu C, Zhu H, Bian H, Wu H, Feng L, Wang J and Liu C (2020) Neutralization mechanism of a monoclonal antibody targeting a porcine circovirus type 2 cap protein conformational epitope. Journal of Virology 94. doi:10.1128/JVI.01836-19.

Jia XX, Wang H, Liu Y, Meng DM, Fan ZC (2020) Development of vaccines for prevention of peste-des-petits-ruminants virus infection. Microbial Pathogenesis 142:104045. doi:10.1016/j.micpath.2020.104045.

Li Y, Lin Y, Xin G, Zhou X, Lu H, Zhang X, Xia X and Sun H (2020) Comparative evaluation of ELPylated virus-like particle vaccine with two commercial PCV2 vaccines by experimental challenge. Vaccine 38:3952-3959. doi:10.1016/j.vaccine.2020.03.060.

Lukosaityte D, Sadeyen JR, Shrestha A, Sealy JE, Bhat S, Chang P, Digard P, Iqbal M (2020) Engineered recombinant single chain variable fragment of monoclonal antibody provides protection to chickens infected with H9N2 avian influenza. Vaccines (Basel) 8. doi:10.3390/vaccines8010118.

Ma F, Zhang E, Li Q, Xu Q, Ou J, Yin H, Li K, Wang L, Zhao X, Niu X, Li X, Zhang S, Wang Y, Deng R, Zhou E and Zhang G (2020) A plant-produced recombinant fusion protein-based Newcastle disease subunit vaccine and rapid differential diagnosis platform. Vaccines (Basel) 8:122. doi:10.3390/vaccines8010122.

Manzoor S, Abubakar M, Zahur AB, Yunus AW, Ullah A and Afzal M (2020) Genetic characterization of peste des petits ruminants virus (Pakistani isolates) and comparative appraisal of diagnostic assays. Transboundary and Emerging Diseases. doi:10.1111/tbed.13563.

Michel-Todó L, Bigey P, Reche PA, Pinazo MJ, Gascón J and Alonso-Padilla J (2020) Design of an epitope-based vaccine ensemble for animal trypanosomiasis by computational methods. Vaccines (Basel) 8:130. doi:10.3390/vaccines8010130.

Njeumi F, Bailey D, Soula JJ, Diop B and Tekola BG (2020) Eradicating the scourge of peste des petits ruminants from the world. Viruses 12. doi:10.3390/v12030313.

Opriessnig T, Forde T, Shimoji Y (2020) Erysipelothrix spp: past, present, and future directions in vaccine research. Frontiers in Veterinary Science 7:174. doi:10.3389/fvets.2020.00174.

Ortega-Sánchez R, Camacho-Nuez M, Castañeda-Ortiz EJ, Martínez-Benítez MB, Hernández-Silva DJ, Aguilar-Tipacamú G and Mosqueda J (2020) Vaccine efficacy of recombinant BmVDAC on Rhipicephalus microplus fed on Babesia bigemina-infected and uninfected cattle. Journal 38(19):3618-3625. doi:10.1016/j.vaccine.2019.12.040.

Osman KM, Kamal OE, Deif HN and Ahmed MM (2020) Phoenix dactylifera, Mentha piperita and Montanide™ ISA-201 as immunological adjuvants in a chicken model. Acta Tropica 202:105281. doi:10.1016/j.actatropica.2019.105281.

Palmer MV, Waters WR and Thacker TC (2020) Vaccination of white-tailed deer (Odocoileus virginianus) with Mycobacterium bovis bacille Calmette-Guérin (BCG) results in positive tuberculin skin test results in a dose-dependent fashion. Research in Veterinary Science 129:70-73. doi:10.1016/j.rvsc.2020.01.010.

Parizi LF, Rangel CK, Sabadin GA, Saggin BF, Kiio I, Xavier MA, da Silva Matos R, Camargo-Mathias MI, Seixas A, Konnai S, Ohashi K, Githaka NW and da Silva Vaz I Jr (2020) Rhipicephalus microplus cystatin as a potential cross-protective tick vaccine against Rhipicephalus appendiculatus. Ticks and Tick-borne Diseases 11:101378. doi:10.1016/j.ttbdis.2020.101378.

Pedrera M, Macchi F, McLean RK, Franceschi V, Thakur N, Russo L, Medfai L, Todd S, Tchilian EZ, Audonnet JC, Chappell K, Isaacs A, Watterson D, Young PR, Marsh GA, Bailey D, Graham SP and Donofrio G (2020) Bovine herpesvirus-4-vectored delivery of Nipah virus glycoproteins enhances T cell immunogenicity in pigs. Vaccines (Basel) 8:115. doi:10.3390/vaccines8010115.

Rupprecht CE, Abela-Ridder B, Abila R, Amparo AC, Banyard A, Blanton J, Chanachai K, Dallmeier K, de Balogh K, Del Rio Vilas V et al (2020) Towards rabies elimination in the Asia-Pacific region: from theory to practice. Biologicals 64:83-95. doi:10.1016/j.biologicals.2020.01.008.

Singanallur NB, Dekker A, Eblé PL, van Hemert-Kluitenberg F, Weerdmeester K, Horsington J and Vosloo W (2020) Emergency foot-and-mouth disease vaccines A Malaysia 97 and A22 Iraq 64 offer good protection against heterologous challenge with a variant serotype A ASIA/G-IX/SEA-97 lineage virus. Vaccines (Basel) 8. doi:10.3390/vaccines8010080.

Smith T, O'Kennedy MM, Wandrag DBR, Adeyemi M and Abolnik C (2020) Efficacy of a plant-produced virus-like particle vaccine in chickens challenged with Influenza A H6N2 virus. Plant Biotechnology Journal 18:502-512. doi:10.1111/pbi.13219.

Sunwoo SY, Noronha LE, Morozov I, Trujillo JD, Kim IJ, Schirtzinger EE, Faburay B, Drolet BS, Urbaniak K, McVey DS, Meekins DA, Palmer MV, Balaraman V, Wilson WC and Richt JA (2020) Evaluation of a baculovirus-expressed VP2 subunit vaccine for the protection of white-tailed deer (Odocoileus virginianus) from epizootic hemorrhagic disease. Vaccines (Basel) 8:59. doi:10.3390/vaccines8010059.

Tang N, Zhang Y, Sadigh Y, Moffat K, Shen Z, Nair V and Yao Y (2020) Generation of a triple insert live avian herpesvirus vectored vaccine using CRISPR/Cas9-based gene editing. Vaccines (Basel) 8:97. doi:10.3390/vaccines8010097.

Teklue T, Sun Y, Abid M, Luo Y and Qiu HJ (2020) Current status and evolving approaches to African swine fever vaccine development. Transboundary and Emerging Diseases 67:529-542. doi:10.1111/tbed.13364.

Wang S, Yang G, Nie J, Yang R, Du M, Su J, Wang J, Wang J and Zhu Y (2020) Recombinant Erns-E2 protein vaccine formulated with MF59 and CPG-ODN promotes T cell immunity against bovine viral diarrhea virus infection. Vaccine 38:3881-3891. doi:10.1016/j.vaccine.2020.03.020.

Williams SC, van Oosterwijk JG, Linske MA, Zatechka S, Richer LM, Przybyszewski C, Wikel SK and Stafford KC III (2020) Administration of an orally delivered substrate targeting a mammalian zoonotic pathogen reservoir population: novel application and biomarker analysis. Vector-Borne and Zoonotic Diseases. doi:10.1089/vbz.2019.2612.

Zhan Y, Yu W, Cai X, Lei X, Lei H, Wang A, Sun Y, Wang N, Deng Z and Yang Y (2020) The carboxyl terminus of the porcine circovirus type 2 capsid protein is critical to virus-like particle assembly, cell entry, and propagation. Journal of Virology 94. doi:10.1128/JVI.00042-20.

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